Photoaging of the skin from phenotype to mechanisms

K Scharffetter–Kochanek, P Brenneisen, J Wenk… - Experimental …, 2000 - Elsevier
The skin is increasingly exposed to ambient UV-irradiation thus increasing its risk for
photooxidative damage with longterm detrimental effects like photoaging, which is
characterized by wrinkles, loss of skin tone, and resilience. Photoaged skin displays
prominent alterations in the cellular component and the extracellular matrix of the connective
tissue with an accumulation of disorganized elastin and its microfibrillar component fibrillin
in the deep dermis and a severe loss of interstitial collagens, the major structural proteins of …