Comparative analysis of interactions of RASSF1-10
JJ Chan, D Flatters, F Rodrigues-Lima, J Yan… - Advances in biological …, 2013 - Elsevier
Members of the RASSF family (RASSF1-10) have been identified as candidate tumour
suppressors that are frequently downregulated by promoter hypermethylation in cancers.
These proteins carry a common Ras-association (RA) and SARAH domain (RASSF1-6) that
can potentially bind Ras oncoproteins and mediate protein–protein interactions with other
SARAH domain proteins. However, there is a notable lack of comparative characterisation of
the RASSF family, as well as molecular and structural information that facilitate their tumour …
suppressors that are frequently downregulated by promoter hypermethylation in cancers.
These proteins carry a common Ras-association (RA) and SARAH domain (RASSF1-6) that
can potentially bind Ras oncoproteins and mediate protein–protein interactions with other
SARAH domain proteins. However, there is a notable lack of comparative characterisation of
the RASSF family, as well as molecular and structural information that facilitate their tumour …