[HTML][HTML] Phosphorylation and inactivation of myeloid cell leukemia 1 by JNK in response to oxidative stress

S Inoshita, K Takeda, T Hatai, Y Terada, M Sano… - Journal of Biological …, 2002 - ASBMB
Oxidative stress induces JNK activation, which leads to apoptosis through mitochondria-
dependent caspase activation. However, little is known about the mechanism by which JNK
alters mitochondrial function. In this study, we investigated the role of phosphorylation of
myeloid cell leukemia 1 (Mcl-1), an anti-apoptotic member of the Bcl-2 family, in oxidative
stress-induced apoptosis. We found that JNK phosphorylated Ser-121 and Thr-163 of Mcl-1
in response to stimulation with H 2 O 2 and that transfection of unphosphorylatable Mcl-1 …