Administration of retinoic acid (RA) prevented the development of experimental allergic
encephalomyelitis (EAE) in Lewis rats. RA suspended in corn oil was given for 3 days before
the expected onset of the disease to rats immunized with myelin and to controls. The drug
suppressed the neurological symptoms as well as the perivascular infiltrates observed in
vehicle-treated animals. The results indicate that under these experimental conditions, RA
has immunosuppressive activity by interfering with the efferent phase of the immune …