[HTML][HTML] The long form of FLIP is an activator of caspase-8 at the Fas death-inducing signaling complex
Death receptors, such as Fas and tumor necrosis factor-related apoptosis-inducing ligand
receptors, recruit Fas-associated death domain and pro-caspase-8 homodimers, which are
then autoproteolytically activated. Active caspase-8 is released into the cytoplasm, where it
cleaves various proteins including pro-caspase-3, resulting in apoptosis. The cellular Fas-
associated death domain-like interleukin-1-β-converting enzyme-inhibitory protein long form
(FLIP L), a structural homologue of caspase-8 lacking caspase activity because of several …
receptors, recruit Fas-associated death domain and pro-caspase-8 homodimers, which are
then autoproteolytically activated. Active caspase-8 is released into the cytoplasm, where it
cleaves various proteins including pro-caspase-3, resulting in apoptosis. The cellular Fas-
associated death domain-like interleukin-1-β-converting enzyme-inhibitory protein long form
(FLIP L), a structural homologue of caspase-8 lacking caspase activity because of several …