[HTML][HTML] TIN2 binds TRF1 and TRF2 simultaneously and stabilizes the TRF2 complex on telomeres
JZS Ye, JR Donigian, M Van Overbeek… - Journal of Biological …, 2004 - ASBMB
Human telomeres contain two related telomeric DNA-binding proteins, TRF1 and TRF2. The
TRF1 complex contains the TRF1 interacting partner, TIN2, as well as PIP1 and POT1 and
regulates telomere-length homeostasis. The TRF2 complex is primarily involved in telomere
protection and contains the TRF2 interacting partner human (h) Rap1 as well as several
factors involved in the DNA damage response. A prior report showed that conditional
deletion of murine TRF1 reduced the presence of TRF2 on telomeres. Here we showed that …
TRF1 complex contains the TRF1 interacting partner, TIN2, as well as PIP1 and POT1 and
regulates telomere-length homeostasis. The TRF2 complex is primarily involved in telomere
protection and contains the TRF2 interacting partner human (h) Rap1 as well as several
factors involved in the DNA damage response. A prior report showed that conditional
deletion of murine TRF1 reduced the presence of TRF2 on telomeres. Here we showed that …