[HTML][HTML] Extracellular matrix-regulated gene expression requires cooperation of SWI/SNF and transcription factors
R Xu, VA Spencer, MJ Bissell - Journal of biological chemistry, 2007 - ASBMB
Extracellular cues play crucial roles in the transcriptional regulation of tissue-specific genes,
but whether and how these signals lead to chromatin remodeling is not understood and
subject to debate. Using chromatin immunoprecipitation assays and mammary-specific
genes as models, we show here that extracellular matrix molecules and prolactin cooperate
to induce histone acetylation and binding of transcription factors and the SWI/SNF complex
to the β-and γ-casein promoters. Introduction of a dominant negative Brg1, an ATPase …
but whether and how these signals lead to chromatin remodeling is not understood and
subject to debate. Using chromatin immunoprecipitation assays and mammary-specific
genes as models, we show here that extracellular matrix molecules and prolactin cooperate
to induce histone acetylation and binding of transcription factors and the SWI/SNF complex
to the β-and γ-casein promoters. Introduction of a dominant negative Brg1, an ATPase …