[HTML][HTML] Sprouty2 inhibits the Ras/MAP kinase pathway by inhibiting the activation of Raf
P Yusoff, DH Lao, SH Ong, ESM Wong, J Lim… - Journal of Biological …, 2002 - ASBMB
Several genetic studies in Drosophilahave shown that the dSprouty (dSpry) protein inhibits
the Ras/mitogen-activated protein (MAP) kinase pathway induced by various activated
receptor tyrosine kinase receptors, most notably those of the epidermal growth factor
receptor (EGFR) and fibroblast growth factor receptor (FGFR). Currently, the mode of action
of dSpry is unknown, and the point of inhibition remains controversial. There are at least four
mammalian Spry isoforms that have been shown to co-express preferentially with FGFRs as …
the Ras/mitogen-activated protein (MAP) kinase pathway induced by various activated
receptor tyrosine kinase receptors, most notably those of the epidermal growth factor
receptor (EGFR) and fibroblast growth factor receptor (FGFR). Currently, the mode of action
of dSpry is unknown, and the point of inhibition remains controversial. There are at least four
mammalian Spry isoforms that have been shown to co-express preferentially with FGFRs as …