[HTML][HTML] AMP-activated protein kinase phosphorylates cardiac troponin I at Ser-150 to increase myofilament calcium sensitivity and blunt PKA-dependent function
BR Nixon, A Thawornkaiwong, J Jin… - Journal of Biological …, 2012 - ASBMB
AMP-activated protein kinase (AMPK) is an energy-sensing enzyme central to the regulation
of metabolic homeostasis. In the heart AMPK is activated during cardiac stress-induced ATP
depletion and functions to stimulate metabolic pathways that restore the AMP/ATP balance.
Recently it was demonstrated that AMPK phosphorylates cardiac troponin I (cTnI) at Ser-150
in vitro. We sought to determine if the metabolic regulatory kinase AMPK phosphorylates
cTnI at Ser-150 in vivo to alter cardiac contractile function directly at the level of the …
of metabolic homeostasis. In the heart AMPK is activated during cardiac stress-induced ATP
depletion and functions to stimulate metabolic pathways that restore the AMP/ATP balance.
Recently it was demonstrated that AMPK phosphorylates cardiac troponin I (cTnI) at Ser-150
in vitro. We sought to determine if the metabolic regulatory kinase AMPK phosphorylates
cTnI at Ser-150 in vivo to alter cardiac contractile function directly at the level of the …