Inducible costimulator (ICOS) is a marker for highly suppressive antigen-specific T cells sharing features of TH17/TH1 and regulatory T cells
M Vocanson, A Rozieres, A Hennino, G Poyet… - Journal of Allergy and …, 2010 - Elsevier
BACKGROUND: CD4+ CD25+ regulatory T (Treg) cells are involved in the downmodulation
of numerous immune responses to pathogens, tumors, or allergens. OBJECTIVE: In this
study, we further characterized the nature of Treg cells that control skin inflammatory
reactions to haptens. METHODS: In a model of contact hypersensitivity to 2, 4-dinitro-
fluorobenzene, we have investigated the phenotype, the specificity, and the origin of Treg
cells that modulate the priming of effector CD8+ T cells responsible for the development of …
of numerous immune responses to pathogens, tumors, or allergens. OBJECTIVE: In this
study, we further characterized the nature of Treg cells that control skin inflammatory
reactions to haptens. METHODS: In a model of contact hypersensitivity to 2, 4-dinitro-
fluorobenzene, we have investigated the phenotype, the specificity, and the origin of Treg
cells that modulate the priming of effector CD8+ T cells responsible for the development of …