Role of Interleukin-6 in the Control of Acute and Chronic Giardia lamblia Infections in Mice
P Zhou, E Li, N Zhu, J Robertson, T Nash… - Infection and …, 2003 - Am Soc Microbiol
P Zhou, E Li, N Zhu, J Robertson, T Nash, SM Singer
Infection and immunity, 2003•Am Soc MicrobiolIn this study, we investigated the role of interleukin-6 (IL-6) in Giardia lamblia infections in
mice. Elevated IL-6 expression was found in wild-type mice 15 days postinfection.
Furthermore, IL-6-deficient mice controlled infections only slowly although normal
immunoglobulin A production was observed. Thus, IL-6 is necessary for early control of
acute G. lamblia infections.
mice. Elevated IL-6 expression was found in wild-type mice 15 days postinfection.
Furthermore, IL-6-deficient mice controlled infections only slowly although normal
immunoglobulin A production was observed. Thus, IL-6 is necessary for early control of
acute G. lamblia infections.
Abstract
In this study, we investigated the role of interleukin-6 (IL-6) in Giardia lamblia infections in mice. Elevated IL-6 expression was found in wild-type mice 15 days postinfection. Furthermore, IL-6-deficient mice controlled infections only slowly although normal immunoglobulin A production was observed. Thus, IL-6 is necessary for early control of acute G. lamblia infections.
American Society for Microbiology