[HTML][HTML] Spatial distribution of di-and tri-methyl lysine 36 of histone H3 at active genes
AJ Bannister, R Schneider, FA Myers… - Journal of Biological …, 2005 - ASBMB
Methylation of lysine 4 of histone H3 (K4/H3) is linked to transcriptional activity, whereas
methylation of K9/H3 is tightly associated with gene inactivity. These are well characterized
sites of methylation within histones, but there are numerous other, less characterized, sites
of modification. In Saccharomyces cerevisiae, methylation of K36/H3 has been linked to
active genes, but little is known about this methylation in higher eukaryotes. Here we
analyzed for the first time the levels and spatial distribution of di-and tri-methyl (di-and tri-Me) …
methylation of K9/H3 is tightly associated with gene inactivity. These are well characterized
sites of methylation within histones, but there are numerous other, less characterized, sites
of modification. In Saccharomyces cerevisiae, methylation of K36/H3 has been linked to
active genes, but little is known about this methylation in higher eukaryotes. Here we
analyzed for the first time the levels and spatial distribution of di-and tri-methyl (di-and tri-Me) …