Fatty acid synthase overexpression in colorectal cancer is associated with microsatellite instability, independent of CpG island methylator phenotype
S Ogino, T Kawasaki, A Ogawa, GJ Kirkner, M Loda… - Human pathology, 2007 - Elsevier
Overexpression of fatty acid synthase (FASN), a key enzyme for de novo lipogenesis, is
observed in many cancers including colorectal cancer and is associated with poor clinical
outcomes. Cellular FASN expression is physiologically upregulated in a state of energy
excess. Obesity and excess energy balance have been known to be risk factors for
colorectal cancer. High degree of microsatellite instability (MSI-H) is a distinct phenotype in
colorectal cancer, associated with CpG island methylator phenotype (CIMP). Previous data …
observed in many cancers including colorectal cancer and is associated with poor clinical
outcomes. Cellular FASN expression is physiologically upregulated in a state of energy
excess. Obesity and excess energy balance have been known to be risk factors for
colorectal cancer. High degree of microsatellite instability (MSI-H) is a distinct phenotype in
colorectal cancer, associated with CpG island methylator phenotype (CIMP). Previous data …