Cigarette smoke–an aging accelerator?

D Bernhard, C Moser, A Backovic, G Wick - Experimental gerontology, 2007 - Elsevier
Cigarette smoking reduces life span by an average of 7 years, and tobacco consumption
accounts for a shortening of disease free life by 14 years. The exact mechanisms by which
smoking causes disease and death are generally not well understood, but evidence
continues to mount that cigarette smoking exhausts cellular defense and repair functions,
leading to an accumulation of damage eg mutations and malfunctioning proteins. In this
review, we make an attempt to ascribe many of the deleterious effects of smoking on human …