CD4+ CD25+ T regulatory cells, immunotherapy of cancer, and interleukin-2

PA Antony, NP Restifo - Journal of immunotherapy, 2005 - journals.lww.com
CD4+ CD25+ T regulatory (T reg) cells control immunologic tolerance to self-antigens and
play a role in suppressing antitumor immune responses, but the mechanism of suppression
in vivo remains uncertain. Recently, signaling through the high-affinity interleukin-2 (IL-2)
receptor has been shown to be critical for T reg cell differentiation and survival in vivo. Mice
deficient in IL-2 or its receptor (CD25 or CD122) or deficient in downstream signaling
molecules, including JAK-3 and STAT-5, do not develop a stable population of T reg cells …