[HTML][HTML] Molecular alterations of h-warts/LATS1 tumor suppressor in human soft tissue sarcoma
M Hisaoka, A Tanaka, H Hashimoto - Laboratory investigation, 2002 - Elsevier
Abstract h-warts/LATS1 is a human homolog of the Drosophila warts tumor suppressor
gene, which functions as a component of the mitotic apparatus. LATS1-deficient (Lats1−/−)
mice have been reported to develop ovarian stromal tumors and soft tissue sarcomas. We
investigated the status of the h-warts/LATS1 in 50 human soft tissue sarcomas to address its
potential function as a tumor suppressor in human sarcoma development. In our RT-PCR
assay, 7 (14%)(3 of 4 myxoid liposarcomas, 3 of 7 leiomyosarcomas, 1 of 9 malignant …
gene, which functions as a component of the mitotic apparatus. LATS1-deficient (Lats1−/−)
mice have been reported to develop ovarian stromal tumors and soft tissue sarcomas. We
investigated the status of the h-warts/LATS1 in 50 human soft tissue sarcomas to address its
potential function as a tumor suppressor in human sarcoma development. In our RT-PCR
assay, 7 (14%)(3 of 4 myxoid liposarcomas, 3 of 7 leiomyosarcomas, 1 of 9 malignant …