Central hypothyroidism in infants who were born to mothers with thyrotoxicosis before 32 weeks' gestation: 3 cases
R Higuchi, M Miyawaki, T Kumagai, T Okutani… - …, 2005 - publications.aap.org
We describe 3 infants who were born to mothers with Graves' disease and developed
central hypothyroidism that persisted for> 6 months after birth. Two were preterm infants, and
the other was a term infant who was born to a euthyroid mother who had been treated with
an antithyroid drug since week 31 of gestation. These cases suggest that passage of thyroid
hormones can occur from a thyrotoxic mother to the fetus and that the gestational period
earlier than 32 weeks may be the critical time for development of central hypothyroidism.
central hypothyroidism that persisted for> 6 months after birth. Two were preterm infants, and
the other was a term infant who was born to a euthyroid mother who had been treated with
an antithyroid drug since week 31 of gestation. These cases suggest that passage of thyroid
hormones can occur from a thyrotoxic mother to the fetus and that the gestational period
earlier than 32 weeks may be the critical time for development of central hypothyroidism.