Stem cell senescence and regenerative paradigms
AP Beltrami, D Cesselli… - Clinical Pharmacology & …, 2012 - Wiley Online Library
AP Beltrami, D Cesselli, CA Beltrami
Clinical Pharmacology & Therapeutics, 2012•Wiley Online LibraryThe term “cellular senescence” denotes a cellular response to several stressors that results
in irreversible growth arrest, alterations of the gene expression profile, epigenetic
modifications, and an altered secretome, all of which eventually impair the reparative
properties of primitive cells, adding a layer of complexity to the field of regenerative
medicine. The purpose of this review is to illustrate how cellular senescence could affect
tissue repair and to propose interventions that aim at interfering with it. Clinical …
in irreversible growth arrest, alterations of the gene expression profile, epigenetic
modifications, and an altered secretome, all of which eventually impair the reparative
properties of primitive cells, adding a layer of complexity to the field of regenerative
medicine. The purpose of this review is to illustrate how cellular senescence could affect
tissue repair and to propose interventions that aim at interfering with it. Clinical …
The term “cellular senescence” denotes a cellular response to several stressors that results in irreversible growth arrest, alterations of the gene expression profile, epigenetic modifications, and an altered secretome, all of which eventually impair the reparative properties of primitive cells, adding a layer of complexity to the field of regenerative medicine. The purpose of this review is to illustrate how cellular senescence could affect tissue repair and to propose interventions that aim at interfering with it.
Clinical Pharmacology & Therapeutics (2012); 91 1, 21–29. doi:10.1038/clpt.2011.262
Wiley Online Library