Autoantibodies to interferon-γ in a patient with selective susceptibility to mycobacterial infection and organ-specific autoimmunity
R Döffinger, MR Helbert… - Clinical Infectious …, 2004 - academic.oup.com
R Döffinger, MR Helbert, G Barcenas-Morales, K Yang, S Dupuis, L Ceron-Gutierrez…
Clinical Infectious Diseases, 2004•academic.oup.comWe evaluated a patient with disseminated Mycobacterium tuberculosis and Mycobacterium
chelonae infection, of which he died. He also developed autoimmune (type I) diabetes and
primary hypothyroidism. His serum contained a high titer of immunoglobulin G autoantibody
to interferon-γ (IFN-γ) capable of blocking in vitro responses to this cytokine by peripheral
blood mononuclear cells from normal donors. These results suggest that autoantibodies to
IFN-γ can induce susceptibility to disseminated mycobacterial infection, which may be …
chelonae infection, of which he died. He also developed autoimmune (type I) diabetes and
primary hypothyroidism. His serum contained a high titer of immunoglobulin G autoantibody
to interferon-γ (IFN-γ) capable of blocking in vitro responses to this cytokine by peripheral
blood mononuclear cells from normal donors. These results suggest that autoantibodies to
IFN-γ can induce susceptibility to disseminated mycobacterial infection, which may be …
Abstract
We evaluated a patient with disseminated Mycobacterium tuberculosis and Mycobacterium chelonae infection, of which he died. He also developed autoimmune (type I) diabetes and primary hypothyroidism. His serum contained a high titer of immunoglobulin G autoantibody to interferon-γ (IFN-γ) capable of blocking in vitro responses to this cytokine by peripheral blood mononuclear cells from normal donors. These results suggest that autoantibodies to IFN-γ can induce susceptibility to disseminated mycobacterial infection, which may be refractory to chemotherapy.
Oxford University Press