Na, K-ATPases of the lens epithelium and fiber cell: formation of catalytic cycle intermediates and Na+: K+ exchange
MH Garner - Experimental eye research, 1994 - Elsevier
Previous studies suggest that an α2-related isoform of the catalytic subunit is predominant in
the lens fiber cells. The α1 isoform is predominant in the lens epithelium (Garner, Horwitz
and Enomoto, 1992). Data are presented to show that strophanthidin-sensitive K+ transport
is sustained by both of these lens Na, K-ATPases. The K 50 for strophanthidin inhibition of
K+ transport was 1· 4±0· 5× 10-6 M for the α1 isoform of the epithelium, 1· 3±0· 6× 10-7 M for
the α2-related isoform of the lens fiber cells. Na+ accumulation in cultured bovine lenses …
the lens fiber cells. The α1 isoform is predominant in the lens epithelium (Garner, Horwitz
and Enomoto, 1992). Data are presented to show that strophanthidin-sensitive K+ transport
is sustained by both of these lens Na, K-ATPases. The K 50 for strophanthidin inhibition of
K+ transport was 1· 4±0· 5× 10-6 M for the α1 isoform of the epithelium, 1· 3±0· 6× 10-7 M for
the α2-related isoform of the lens fiber cells. Na+ accumulation in cultured bovine lenses …