[HTML][HTML] Oxidative inactivation of the lipid phosphatase phosphatase and tensin homolog on chromosome ten (PTEN) as a novel mechanism of acquired long QT …
X Wan, AT Dennis, C Obejero-Paz, JL Overholt… - Journal of biological …, 2011 - ASBMB
The most common cause of cardiac side effects of pharmaco-therapy is acquired long QT
syndrome, which is characterized by abnormal cardiac repolarization and most often caused
by direct blockade of the cardiac potassium channel human ether a-go-go-related gene
(hERG). However, little is known about therapeutic compounds that target ion channels
other than hERG. We have discovered that arsenic trioxide (As 2 O 3), a very potent
antineoplastic compound for the treatment of acute promyelocytic leukemia, is proarrhythmic …
syndrome, which is characterized by abnormal cardiac repolarization and most often caused
by direct blockade of the cardiac potassium channel human ether a-go-go-related gene
(hERG). However, little is known about therapeutic compounds that target ion channels
other than hERG. We have discovered that arsenic trioxide (As 2 O 3), a very potent
antineoplastic compound for the treatment of acute promyelocytic leukemia, is proarrhythmic …