[HTML][HTML] Disrupting the circadian clock: gene-specific effects on aging, cancer, and other phenotypes
AY Elizabeth, DR Weaver - Aging (Albany NY), 2011 - ncbi.nlm.nih.gov
AY Elizabeth, DR Weaver
Aging (Albany NY), 2011•ncbi.nlm.nih.govThe circadian clock imparts 24-hour rhythmicity on gene expression and cellular physiology
in virtually all cells. Disruption of the genes necessary for the circadian clock to function has
diverse effects, including aging-related phenotypes. Some circadian clock genes have been
described as tumor suppressors, while other genes have less clear functions in aging and
cancer. In this Review, we highlight a recent study [Dubrovsky et al., Aging 2: 936-944, 2010]
and discuss the much larger field examining the relationship between circadian clock genes …
in virtually all cells. Disruption of the genes necessary for the circadian clock to function has
diverse effects, including aging-related phenotypes. Some circadian clock genes have been
described as tumor suppressors, while other genes have less clear functions in aging and
cancer. In this Review, we highlight a recent study [Dubrovsky et al., Aging 2: 936-944, 2010]
and discuss the much larger field examining the relationship between circadian clock genes …
Abstract
The circadian clock imparts 24-hour rhythmicity on gene expression and cellular physiology in virtually all cells. Disruption of the genes necessary for the circadian clock to function has diverse effects, including aging-related phenotypes. Some circadian clock genes have been described as tumor suppressors, while other genes have less clear functions in aging and cancer. In this Review, we highlight a recent study [Dubrovsky et al., Aging 2: 936-944, 2010] and discuss the much larger field examining the relationship between circadian clock genes, circadian rhythmicity, aging-related phenotypes, and cancer.
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