CLOCK and NPAS2 have overlapping roles in the suprachiasmatic circadian clock

JP DeBruyne, DR Weaver, SM Reppert - Nature neuroscience, 2007 - nature.com
JP DeBruyne, DR Weaver, SM Reppert
Nature neuroscience, 2007nature.com
Heterodimers of CLOCK and BMAL1, bHLH-PAS transcription factors, are believed to be the
major transcriptional regulators of the circadian clock mechanism in mammals. However, a
recent study shows that CLOCK-deficient mice continue to exhibit robust behavioral and
molecular rhythms. Here we report that the transcription factor NPAS2 (MOP4) is able to
functionally substitute for CLOCK in the master brain clock in mice to regulate circadian
rhythmicity.
Abstract
Heterodimers of CLOCK and BMAL1, bHLH-PAS transcription factors, are believed to be the major transcriptional regulators of the circadian clock mechanism in mammals. However, a recent study shows that CLOCK-deficient mice continue to exhibit robust behavioral and molecular rhythms. Here we report that the transcription factor NPAS2 (MOP4) is able to functionally substitute for CLOCK in the master brain clock in mice to regulate circadian rhythmicity.
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