Alterations in the circadian rest-activity rhythm in aging and Alzheimer's disease
W Witting, IH Kwa, P Eikelenboom, M Mirmiran… - Biological …, 1990 - Elsevier
The suprachiasmatic nucleus, considered to be the endogenous circadian clock in the
mammalian brain, shows morphological changes with aging, which become even more
pronounced in Alzheimer's disease (AD). In order to assess possible functional implications
of these alterations, circadian rest-activity rhythms of 6 young and 13 old volunteers and of
12 AD patients were studied with a recently developed ambulatory rest-activity monitor
(RA24). Young and old volunteers showed no differences in their rest-activity rhythm in any …
mammalian brain, shows morphological changes with aging, which become even more
pronounced in Alzheimer's disease (AD). In order to assess possible functional implications
of these alterations, circadian rest-activity rhythms of 6 young and 13 old volunteers and of
12 AD patients were studied with a recently developed ambulatory rest-activity monitor
(RA24). Young and old volunteers showed no differences in their rest-activity rhythm in any …