[HTML][HTML] The expression of endothelial nitric-oxide synthase is controlled by a cell-specific histone code
Expression of endothelial nitric-oxide synthase (eNOS) mRNA is highly restricted to the
endothelial cell layer of medium to large sized arterial blood vessels. Here we assessed the
chromatin environment of the eNOS gene in expressing and nonexpressing cell types.
Within endothelial cells, but not a variety of nonendothelial cells, the nucleosomes that
encompassed the eNOS core promoter and proximal downstream coding regions were
highly enriched in acetylated histones H3 and H4 and methylated lysine 4 of histone H3 …
endothelial cell layer of medium to large sized arterial blood vessels. Here we assessed the
chromatin environment of the eNOS gene in expressing and nonexpressing cell types.
Within endothelial cells, but not a variety of nonendothelial cells, the nucleosomes that
encompassed the eNOS core promoter and proximal downstream coding regions were
highly enriched in acetylated histones H3 and H4 and methylated lysine 4 of histone H3 …