RhoA activation and increased intracellular Ca 2+ concentration mediated by the activation
of transient receptor potential channels (TRPC) both contribute to the thrombin-induced
increase in endothelial cell contraction, cell shape change, and consequently to the
mechanism of increased endothelial permeability. Herein, we addressed the possibility that
TRPC signals RhoA activation and thereby contributes in actinomyosin-mediated
endothelial cell contraction and increased endothelial permeability. Transduction of a …