[HTML][HTML] Identification of ML204, a novel potent antagonist that selectively modulates native TRPC4/C5 ion channels
M Miller, J Shi, Y Zhu, M Kustov, J Tian… - Journal of Biological …, 2011 - ASBMB
Transient receptor potential canonical (TRPC) channels are Ca 2+-permeable nonselective
cation channels implicated in diverse physiological functions, including smooth muscle
contractility and synaptic transmission. However, lack of potent selective pharmacological
inhibitors for TRPC channels has limited delineation of the roles of these channels in
physiological systems. Here we report the identification and characterization of ML204 as a
novel, potent, and selective TRPC4 channel inhibitor. A high throughput fluorescent screen …
cation channels implicated in diverse physiological functions, including smooth muscle
contractility and synaptic transmission. However, lack of potent selective pharmacological
inhibitors for TRPC channels has limited delineation of the roles of these channels in
physiological systems. Here we report the identification and characterization of ML204 as a
novel, potent, and selective TRPC4 channel inhibitor. A high throughput fluorescent screen …