Dysregulated postsynaptic density and endocytic zone in the amygdala of human heroin and cocaine abusers
A Ökvist, P Fagergren, J Whittard, A Garcia-Osta… - Biological …, 2011 - Elsevier
BACKGROUND:: Glutamatergic transmission in the amygdala is hypothesized as an
important mediator of stimulus-reward associations contributing to drug-seeking behavior
and relapse. Insight is, however, lacking regarding the amygdala glutamatergic system in
human drug abusers. METHODS:: We examined glutamate receptors and scaffolding
proteins associated with the postsynaptic density in the human postmortem amygdala.
Messenger RNA or protein levels were studied in a population of multidrug (seven heroin …
important mediator of stimulus-reward associations contributing to drug-seeking behavior
and relapse. Insight is, however, lacking regarding the amygdala glutamatergic system in
human drug abusers. METHODS:: We examined glutamate receptors and scaffolding
proteins associated with the postsynaptic density in the human postmortem amygdala.
Messenger RNA or protein levels were studied in a population of multidrug (seven heroin …