[PDF][PDF] Deregulated BCL6 expression recapitulates the pathogenesis of human diffuse large B cell lymphomas in mice

G Cattoretti, L Pasqualucci, G Ballon, W Tam… - Cancer cell, 2005 - cell.com
G Cattoretti, L Pasqualucci, G Ballon, W Tam, SV Nandula, Q Shen, T Mo, VV Murty
Cancer cell, 2005cell.com
Diffuse large B cell lymphomas (DLBCL) derive from germinal center (GC) B cells and
display chromosomal alterations deregulating the expression of BCL6, a transcriptional
repressor required for GC formation. To investigate the role of BCL6 in DLBCL
pathogenesis, we have engineered mice that express BCL6 constitutively in B cells by
mimicking a chromosomal translocation found in human DLBCL. These mice display
increased GC formation and perturbed post-GC differentiation characterized by a decreased …
Summary
Diffuse large B cell lymphomas (DLBCL) derive from germinal center (GC) B cells and display chromosomal alterations deregulating the expression of BCL6, a transcriptional repressor required for GC formation. To investigate the role of BCL6 in DLBCL pathogenesis, we have engineered mice that express BCL6 constitutively in B cells by mimicking a chromosomal translocation found in human DLBCL. These mice display increased GC formation and perturbed post-GC differentiation characterized by a decreased number of post-isotype switch plasma cells. Subsequently, these mice develop a lymphoproliferative syndrome that culminates with the development of lymphomas displaying features typical of human DLBCL. These results define the oncogenic role of BCL6 in the pathogenesis of DLBCL and provide a faithful mouse model of this common disease.
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