[HTML][HTML] HDAC6 regulates mutant SOD1 aggregation through two SMIR motifs and tubulin acetylation

J Gal, J Chen, KR Barnett, L Yang, E Brumley… - Journal of Biological …, 2013 - ASBMB
Histone deacetylase 6 (HDAC6) is a tubulin deacetylase that regulates protein aggregation
and turnover. Mutations in Cu/Zn superoxide dismutase (SOD1) linked to familial
amyotrophic lateral sclerosis (ALS) make the mutant protein prone to aggregation. However,
the role of HDAC6 in mutant SOD1 aggregation and the ALS etiology is unclear. Here we
report that HDAC6 knockdown increased mutant SOD1 aggregation in cultured cells.
Different from its known role in mediating the degradation of poly-ubiquitinated proteins …