Signalling via class IA PI3Ks
L Stephens, P Hawkins - Advances in enzyme regulation, 2011 - Elsevier
Phosphoinositide 3-kinases (PI3Ks) are lipid kinases that use the g-phosphate of ATP to 3-
phosphorylate phosphoinositides on the inositol moiety. Their lipid products, the 3-
phosphorylated phosphoinositides, are ubiquitous intracellular messengers that carry
signals relevant to a huge range of cell functions in both health and disease. There are three
classes of PI3K. The class II PI3Ks are thought to be large, monomeric, multi-domain
proteins that primarily use phosphatidylinositol (PtdIns) as a substrate to create PtdIns3P …
phosphorylate phosphoinositides on the inositol moiety. Their lipid products, the 3-
phosphorylated phosphoinositides, are ubiquitous intracellular messengers that carry
signals relevant to a huge range of cell functions in both health and disease. There are three
classes of PI3K. The class II PI3Ks are thought to be large, monomeric, multi-domain
proteins that primarily use phosphatidylinositol (PtdIns) as a substrate to create PtdIns3P …