Strong association of MuSK antibody–positive myasthenia gravis and HLA-DR14-DQ5
EH Niks, JBM Kuks, BO Roep, GW Haasnoot… - Neurology, 2006 - AAN Enterprises
EH Niks, JBM Kuks, BO Roep, GW Haasnoot, W Verduijn, B Ballieux, MH De Baets…
Neurology, 2006•AAN EnterprisesThe authors studied the HLA profile of 23 white Dutch patients with muscle-specific kinase
antibody–positive myasthenia gravis (MuSK Ab+ MG) and found an association with HLA-
DR14-DQ5 (odds ratio 8.5; 95% CI 3.9 to 18.7; p= 4.9× 10− 5). Fifty-two percent of the
patients carried the DR14 allele compared with 5% of the controls (p= 1.0× 10− 8). This
association between MuSK Ab+ MG and a relatively rare HLA haplotype differs from the
previously described association of early-onset acetylcholine receptor Ab+ MG with HLA-B8 …
antibody–positive myasthenia gravis (MuSK Ab+ MG) and found an association with HLA-
DR14-DQ5 (odds ratio 8.5; 95% CI 3.9 to 18.7; p= 4.9× 10− 5). Fifty-two percent of the
patients carried the DR14 allele compared with 5% of the controls (p= 1.0× 10− 8). This
association between MuSK Ab+ MG and a relatively rare HLA haplotype differs from the
previously described association of early-onset acetylcholine receptor Ab+ MG with HLA-B8 …
The authors studied the HLA profile of 23 white Dutch patients with muscle-specific kinase antibody–positive myasthenia gravis (MuSK Ab+ MG) and found an association with HLA-DR14-DQ5 (odds ratio 8.5; 95% CI 3.9 to 18.7; p = 4.9 × 10−5). Fifty-two percent of the patients carried the DR14 allele compared with 5% of the controls (p = 1.0 × 10−8). This association between MuSK Ab+ MG and a relatively rare HLA haplotype differs from the previously described association of early-onset acetylcholine receptor Ab+ MG with HLA-B8-DR3.
American Academy of Neurology