Myasthenic immunoglobulin accelerates acetylcholine receptor degradation
I Kao, DB Drachman - Science, 1977 - science.org
I Kao, DB Drachman
Science, 1977•science.orgDegradation of acetylcholine receptors by cultured rat skeletal muscle cells was determined
from the release of 125I from bound 125I-labeled α-bungarotoxin. Addition of
immunoglobulin from patients with myasthenia gravis to the culture medium accelerated the
degradation rate to a mean of 8.51±0.44 percent per hour, compared with the mean control
rate of 3.97±0.14 percent per hour (P<<. 001). A similar mechanism may possibly be
involved in the autoimmune pathogenesis of myasthenia gravis in man.
from the release of 125I from bound 125I-labeled α-bungarotoxin. Addition of
immunoglobulin from patients with myasthenia gravis to the culture medium accelerated the
degradation rate to a mean of 8.51±0.44 percent per hour, compared with the mean control
rate of 3.97±0.14 percent per hour (P<<. 001). A similar mechanism may possibly be
involved in the autoimmune pathogenesis of myasthenia gravis in man.
Degradation of acetylcholine receptors by cultured rat skeletal muscle cells was determined from the release of 125I from bound 125I-labeled α-bungarotoxin. Addition of immunoglobulin from patients with myasthenia gravis to the culture medium accelerated the degradation rate to a mean of 8.51 ± 0.44 percent per hour, compared with the mean control rate of 3.97 ± 0.14 percent per hour (P < <.001). A similar mechanism may possibly be involved in the autoimmune pathogenesis of myasthenia gravis in man.
AAAS