Autophagy, a highly conserved cellular mechanism wherein various cellular components
are broken down and recycled through lysosomes, occurs constitutively in the heart and may
serve as a cardioprotective mechanism in some situations. It has been implicated in the
development of heart failure and is up-regulated following ischemia-reperfusion injury.
Autophagic flux, a measure of autophagic vesicle formation and clearance, is an important
measurement in evaluating the efficacy of the pathway, however, tools to measure flux in …