Mice with DNA repair gene Ercc1 deficiency in a neural crest lineage are a model for late-onset Hirschsprung disease
J Selfridge, L Song, DG Brownstein, DW Melton - DNA repair, 2010 - Elsevier
The Ercc1 gene is essential for nucleotide excision repair and is also important in
recombination repair and the repair of interstrand crosslinks. We have previously used a
floxed Ercc1 allele with a keratinocyte-specific Cre recombinase transgene to inactivate
Ercc1 in the epidermal layer of the skin and so generate a mouse model for UV-induced non-
melanoma skin cancer. Now, in an attempt to generate a model for UV-induced melanoma,
we have used the floxed Ercc1 allele in combination with a Cre transgene under the control …
recombination repair and the repair of interstrand crosslinks. We have previously used a
floxed Ercc1 allele with a keratinocyte-specific Cre recombinase transgene to inactivate
Ercc1 in the epidermal layer of the skin and so generate a mouse model for UV-induced non-
melanoma skin cancer. Now, in an attempt to generate a model for UV-induced melanoma,
we have used the floxed Ercc1 allele in combination with a Cre transgene under the control …