[HTML][HTML] Enteroviral protease 2A directly cleaves dystrophin and is inhibited by a dystrophin-based substrate analogue

C Badorff, N Berkely, S Mehrotra, JW Talhouk… - Journal of Biological …, 2000 - ASBMB
Enteroviruses such as Coxsackievirus B3 can cause dilated cardiomyopathy through
unknown pathological mechanism (s). Dystrophin is a large extrasarcomeric cytoskeletal
protein whose genetic deficiency causes hereditary dilated cardiomyopathy. In addition, we
have recently shown that dystrophin is proteolytically cleaved by the Coxsackievirus
protease 2A leading to functional impairment and morphological disruption. However, the
mechanism of dystrophin cleavage and the exact cleavage site remained to be identified …