[HTML][HTML] Cardiomyopathy associated with microcirculation dysfunction in laminin α4 chain-deficient mice
J Wang, M Hoshijima, J Lam, Z Zhou, A Jokiel… - Journal of Biological …, 2006 - ASBMB
Laminin α4 chain is a component of extracellular matrix (ECM) laminin-8 and-9 and serves
dual roles as a structure protein and as a signaling molecule. The abundance of laminin α4
chain transcripts in the heart suggests an important role of this protein in cardiovascular
development and function. In this study, we demonstrate that laminin α4 deficient mice
gradually develop cardiac hypertrophy with impaired function. We show that depletion of
laminin α4 chain did not alter the levels of dystrophin-glycoprotein complex (DGC) …
dual roles as a structure protein and as a signaling molecule. The abundance of laminin α4
chain transcripts in the heart suggests an important role of this protein in cardiovascular
development and function. In this study, we demonstrate that laminin α4 deficient mice
gradually develop cardiac hypertrophy with impaired function. We show that depletion of
laminin α4 chain did not alter the levels of dystrophin-glycoprotein complex (DGC) …