[HTML][HTML] Human alveolar type II cells secrete and absorb liquid in response to local nucleotide signaling
PF Bove, BR Grubb, SF Okada, CMP Ribeiro… - Journal of biological …, 2010 - ASBMB
A balance sheet describing the integrated homeostasis of secretion, absorption, and surface
movement of liquids on pulmonary surfaces has remained elusive. It remains unclear
whether the alveolus exhibits an intra-alveolar ion/liquid transport physiology or whether it
secretes ions/liquid that may communicate with airway surfaces. Studies employing isolated
human alveolar type II (AT2) cells were utilized to investigate this question. Human AT2 cells
exhibited both epithelial Na+ channel-mediated Na+ absorption and cystic fibrosis …
movement of liquids on pulmonary surfaces has remained elusive. It remains unclear
whether the alveolus exhibits an intra-alveolar ion/liquid transport physiology or whether it
secretes ions/liquid that may communicate with airway surfaces. Studies employing isolated
human alveolar type II (AT2) cells were utilized to investigate this question. Human AT2 cells
exhibited both epithelial Na+ channel-mediated Na+ absorption and cystic fibrosis …