[HTML][HTML] Integrin α6β4 defines a novel lung epithelial progenitor cell: a step forward for cell-based therapies for pulmonary disease

JA Whitsett, VV Kalinichenko - The Journal of clinical …, 2011 - Am Soc Clin Investig
JA Whitsett, VV Kalinichenko
The Journal of clinical investigation, 2011Am Soc Clin Investig
The many challenges associated with lung transplantation provide a strong rationale for the
development of cell-and tissue-based therapies for patients with respiratory failure caused
by the loss of lung tissue that is associated with chronic pulmonary disease, injury, or
resection. In this issue of the JCI, Chapman et al. take an important step forward in the
development of regenerative medicine for the treatment of lung disease by identifying a
novel integrin α6β4–expressing alveolar epithelial cell that serves as a multipotent …
The many challenges associated with lung transplantation provide a strong rationale for the development of cell- and tissue-based therapies for patients with respiratory failure caused by the loss of lung tissue that is associated with chronic pulmonary disease, injury, or resection. In this issue of the JCI, Chapman et al. take an important step forward in the development of regenerative medicine for the treatment of lung disease by identifying a novel integrin α6β4–expressing alveolar epithelial cell that serves as a multipotent progenitor during repair of the severely injured lung.
The Journal of Clinical Investigation