The nuclear receptor superfamily: the second decade
Cell, 1995•cell.com
We have identified and characterized two genes in Drosophila whose products are required
for activated RAS to signal with normal efficiency, but do not appear to effect signaling by
activated RAF. One encodes the β subunit of type I geranylgeranyl transferase, a prenylation
enzyme essential for targeting RAS to the plasma membrane. The other encodes a protein
kinase that we have named kinase suppressor of ras (ksr). By genetic criteria, we show that
KSR functions in multiple receptor tyrosine kinase pathways.
for activated RAS to signal with normal efficiency, but do not appear to effect signaling by
activated RAF. One encodes the β subunit of type I geranylgeranyl transferase, a prenylation
enzyme essential for targeting RAS to the plasma membrane. The other encodes a protein
kinase that we have named kinase suppressor of ras (ksr). By genetic criteria, we show that
KSR functions in multiple receptor tyrosine kinase pathways.
We have identified and characterized two genes in Drosophila whose products are required for activated RAS to signal with normal efficiency, but do not appear to effect signaling by activated RAF. One encodes the β subunit of type I geranylgeranyl transferase, a prenylation enzyme essential for targeting RAS to the plasma membrane. The other encodes a protein kinase that we have named kinase suppressor of ras (ksr). By genetic criteria, we show that KSR functions in multiple receptor tyrosine kinase pathways.
cell.com