A synthesis of labeled ethidium bromide
RDN Bastos, HR Mahler - Archives of Biochemistry and Biophysics, 1974 - Elsevier
RDN Bastos, HR Mahler
Archives of Biochemistry and Biophysics, 1974•ElsevierA method is described for the synthesis of labeled ethidium (3, 8-diamino-5-ethyl-6-phenyl
phenanthridinium) bromide. Based on benzoic acid, the radioactive precursor used, the
yield is 15% of a compound that is indistinguishable from authentic ethidium bromide in its
absorption spectra (uv, visible, ir), Chromatographie behavior, and mutagenic effectiveness
in the induction of respiration-deficient cell lines in baker's yeast.
phenanthridinium) bromide. Based on benzoic acid, the radioactive precursor used, the
yield is 15% of a compound that is indistinguishable from authentic ethidium bromide in its
absorption spectra (uv, visible, ir), Chromatographie behavior, and mutagenic effectiveness
in the induction of respiration-deficient cell lines in baker's yeast.
Abstract
A method is described for the synthesis of labeled ethidium (3,8-diamino-5-ethyl-6-phenyl phenanthridinium) bromide. Based on benzoic acid, the radioactive precursor used, the yield is 15% of a compound that is indistinguishable from authentic ethidium bromide in its absorption spectra (uv, visible, ir), Chromatographie behavior, and mutagenic effectiveness in the induction of respiration-deficient cell lines in baker's yeast.
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