[HTML][HTML] Oxidative modification of nuclear mitogen-activated protein kinase phosphatase 1 is involved in transforming growth factor β1-induced expression of …
RM Liu, J Choi, JH Wu, KAG Pravia, KM Lewis… - Journal of Biological …, 2010 - ASBMB
Transforming growth factor β (TGF-β) stimulates reactive oxygen species (ROS) production
in various cell types, which mediates many of the effects of TGF-β. The molecular
mechanisms whereby TGF-β increases ROS production and ROS modulate the signaling
processes of TGF-β, however, remain poorly defined. In this study, we show that TGF-β1
stimulates NADPH oxidase 4 (Nox4) expression and ROS generation in the nucleus of
murine embryo fibroblasts (NIH3T3 cells). This is associated with an increase in protein thiol …
in various cell types, which mediates many of the effects of TGF-β. The molecular
mechanisms whereby TGF-β increases ROS production and ROS modulate the signaling
processes of TGF-β, however, remain poorly defined. In this study, we show that TGF-β1
stimulates NADPH oxidase 4 (Nox4) expression and ROS generation in the nucleus of
murine embryo fibroblasts (NIH3T3 cells). This is associated with an increase in protein thiol …