[HTML][HTML] Involvement of calcineurin in transforming growth factor-β-mediated regulation of extracellular matrix accumulation
JL Gooch, Y Gorin, BX Zhang, HE Abboud - Journal of Biological Chemistry, 2004 - ASBMB
Calcineurin is a calcium-dependent, serine/threonine phosphatase that functions as a
signaling intermediate. In this study, we investigated the role of calcineurin in transforming
growth factor-β (TGF-β)-mediated cellular effects and examined the signaling pathway
involved in activation of calcineurin. Calcineurin is activated by TGF-β in a time-and dose-
dependent manner. Consistent with increased phosphatase activity, the calcineurin
substrate, NFATc1, is dephosphorylated and transported to the nucleus. Inhibition of …
signaling intermediate. In this study, we investigated the role of calcineurin in transforming
growth factor-β (TGF-β)-mediated cellular effects and examined the signaling pathway
involved in activation of calcineurin. Calcineurin is activated by TGF-β in a time-and dose-
dependent manner. Consistent with increased phosphatase activity, the calcineurin
substrate, NFATc1, is dephosphorylated and transported to the nucleus. Inhibition of …