Activating and inhibitory functions of DAP12
IR Turnbull, M Colonna - Nature Reviews Immunology, 2007 - nature.com
Nature Reviews Immunology, 2007•nature.com
When associated with different receptors, the signalling adaptor DAP12 has been shown to
both potentiate and attenuate the activation of leukocytes. But how can a protein with a
single signalling motif elicit qualitatively different cellular responses? We describe a model
of DAP12 function, whereby the quality of the cellular response (activation or inhibition) is
modulated by the avidity of the interaction between the DAP12-associated receptor and its
ligand. This model extends from previous studies of inhibitory signalling mediated by other …
both potentiate and attenuate the activation of leukocytes. But how can a protein with a
single signalling motif elicit qualitatively different cellular responses? We describe a model
of DAP12 function, whereby the quality of the cellular response (activation or inhibition) is
modulated by the avidity of the interaction between the DAP12-associated receptor and its
ligand. This model extends from previous studies of inhibitory signalling mediated by other …
Abstract
When associated with different receptors, the signalling adaptor DAP12 has been shown to both potentiate and attenuate the activation of leukocytes. But how can a protein with a single signalling motif elicit qualitatively different cellular responses? We describe a model of DAP12 function, whereby the quality of the cellular response (activation or inhibition) is modulated by the avidity of the interaction between the DAP12-associated receptor and its ligand. This model extends from previous studies of inhibitory signalling mediated by other adaptors, such as the Fc-receptor γ-chain and CD3ζ, and provides a potential mechanism for the conflicting phenotypes observed in studies of DAP12-deficient mice.
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