Regulation of accumulation and function of myeloid derived suppressor cells in different murine models of hepatocellular carcinoma
T Kapanadze, J Gamrekelashvili, C Ma, C Chan… - Journal of …, 2013 - Elsevier
Background & Aims Myeloid derived suppressor cells (MDSC) are immature myeloid cells
with immunosuppressive activity. They accumulate in tumor-bearing mice and humans with
different types of cancer, including hepatocellular carcinoma (HCC). The aim of this study
was to examine the biology of MDSC in murine HCC models and to identify a model, which
mimics the human disease. Methods The comparative analysis of MDSC was performed in
mice, bearing transplantable, diethylnitrosoamine (DEN)-induced and MYC-expressing …
with immunosuppressive activity. They accumulate in tumor-bearing mice and humans with
different types of cancer, including hepatocellular carcinoma (HCC). The aim of this study
was to examine the biology of MDSC in murine HCC models and to identify a model, which
mimics the human disease. Methods The comparative analysis of MDSC was performed in
mice, bearing transplantable, diethylnitrosoamine (DEN)-induced and MYC-expressing …