In vitro and in vivo antitumor properties of a T-cell clone generated from murine tumor-infiltrating lymphocytes
BA Fox, PJ Spiess, A Kasid, R Puri, JJ Mulé… - Journal of …, 1990 - journals.lww.com
We have shown that a T-cell clone derived from murine tumorinfiltrating lymphocytes (TILs)
can be established that mediates in vitro and in vivo antitumor effects. Utilizing this clone as
a model, we examined the effect of cytokines on T-cell antitumor effector mechanisms in vitro
and in vivo. This clone, termed BF-1, was generated by limiting dilution culture of a freshly
excised MC-38 tumor, growing it in low levels of interleukin-2 (IL-2), and has been
maintained for over 600 days. This clone became specifically cytotoxic for the MC-38 tumor …
can be established that mediates in vitro and in vivo antitumor effects. Utilizing this clone as
a model, we examined the effect of cytokines on T-cell antitumor effector mechanisms in vitro
and in vivo. This clone, termed BF-1, was generated by limiting dilution culture of a freshly
excised MC-38 tumor, growing it in low levels of interleukin-2 (IL-2), and has been
maintained for over 600 days. This clone became specifically cytotoxic for the MC-38 tumor …