IL-10 suppresses Th17 cells and promotes regulatory T cells in the CD4+ T cell population of rheumatoid arthritis patients
Interleukin-17-producing CD4+ T cells (Th17 cells) are the dominant pathogenic cellular
component in autoimmune inflammatory diseases, including autoimmune arthritis. IL-10
promotes the generation of Foxp3+ regulatory T cells via the IL-10 receptor signal. The
objective of this study was to examine whether IL-10, which acts as an anti-inflammatory
cytokine, has a suppressive effect on the activation of human Th17 cells. Expression of IL-17
and IL-10 was examined immunohistochemically in tissue obtained from rheumatoid arthritis …
component in autoimmune inflammatory diseases, including autoimmune arthritis. IL-10
promotes the generation of Foxp3+ regulatory T cells via the IL-10 receptor signal. The
objective of this study was to examine whether IL-10, which acts as an anti-inflammatory
cytokine, has a suppressive effect on the activation of human Th17 cells. Expression of IL-17
and IL-10 was examined immunohistochemically in tissue obtained from rheumatoid arthritis …