Leptin and the central nervous system control of glucose metabolism

GJ Morton, MW Schwartz - Physiological reviews, 2011 - journals.physiology.org
GJ Morton, MW Schwartz
Physiological reviews, 2011journals.physiology.org
The regulation of body fat stores and blood glucose levels is critical for survival. This review
highlights growing evidence that leptin action in the central nervous system plays a key role
in both processes. Investigation into underlying mechanisms has begun to clarify the
physiological role of leptin in the control of glucose metabolism and raises interesting new
possibilities for the treatment of diabetes and related disorders.
The regulation of body fat stores and blood glucose levels is critical for survival. This review highlights growing evidence that leptin action in the central nervous system plays a key role in both processes. Investigation into underlying mechanisms has begun to clarify the physiological role of leptin in the control of glucose metabolism and raises interesting new possibilities for the treatment of diabetes and related disorders.
American Physiological Society