Satellite cell dysfunction and impaired IGF-1 signaling cause CKD-induced muscle atrophy
L Zhang, XH Wang, H Wang, J Du… - Journal of the American …, 2010 - journals.lww.com
Muscle wasting in chronic kidney disease (CKD) begins with impaired insulin/IGF-1
signaling, causing abnormal protein metabolism. In certain models of muscle atrophy,
reduced satellite cell function contributes to atrophy, but how CKD affects satellite cell
function is unknown. Here, we found that isolated satellite cells from mice with CKD had less
MyoD, the master switch of satellite cell activation, and suppressed myotube formation
compared with control mice. In vivo, CKD delayed the regeneration of injured muscle and …
signaling, causing abnormal protein metabolism. In certain models of muscle atrophy,
reduced satellite cell function contributes to atrophy, but how CKD affects satellite cell
function is unknown. Here, we found that isolated satellite cells from mice with CKD had less
MyoD, the master switch of satellite cell activation, and suppressed myotube formation
compared with control mice. In vivo, CKD delayed the regeneration of injured muscle and …