Higher levels of heat shock proteins in longer-lived mammals and birds
KD Salway, EJ Gallagher, MM Page… - Mechanisms of ageing and …, 2011 - Elsevier
Cellular stress resistance is generally associated with longevity, but the mechanisms
underlying this phenotype are not clear. In invertebrate models there is a clear role for heat
shock proteins (Hsps) and organelle-specific unfolded protein responses (UPR) in longevity.
However, this has not been demonstrated in vertebrates. Some Hsp amino acid sequences
are highly conserved amongst mammals and birds. We used antibodies recognizing
conserved regions of Hsp60 (primarily mitochondrial), Hsp70 (primarily cytosolic), GRP78 …
underlying this phenotype are not clear. In invertebrate models there is a clear role for heat
shock proteins (Hsps) and organelle-specific unfolded protein responses (UPR) in longevity.
However, this has not been demonstrated in vertebrates. Some Hsp amino acid sequences
are highly conserved amongst mammals and birds. We used antibodies recognizing
conserved regions of Hsp60 (primarily mitochondrial), Hsp70 (primarily cytosolic), GRP78 …